2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1834):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137658
    Purine riboside triphosphate
    Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM.
    Purine riboside triphosphate
  • HY-103694
    Nebularine
    		98.44%
    Nebularine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Nebularine
  • HY-160129
    Centanamycin
    Centanamycin (ML-970; AS-I-145; NSC 716970) is a novel DNA-binding agent, and shows cytotoxic activity, with an average GI50 of 34 nM in NCI-60 cell line screening.
    Centanamycin
  • HY-104017
    DMT-2'-O-MOE-rA(Bz) phosphoramidite
    		≥98.0%
    DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenine nucleoside analog. DMT-2'-O-MOE-rA(Bz) phosphoramidite can be used in research on oligonucleotide synthesis.
    DMT-2'-O-MOE-rA(Bz) phosphoramidite
  • HY-128710
    2'-Fluorothymidine
    		99.07%
    2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2).
    2'-Fluorothymidine
  • HY-90006S2
    5-Fluorouracil-15N2
    		Inhibitor ≥99.0%
    5-Fluorouracil-15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV.
    5-Fluorouracil-<sup>15</sup>N<sub>2</sub>
  • HY-W020098
    2'-C-methyluridine
    2'-C-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    2'-C-methyluridine
  • HY-154366
    5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite
    		≥98.0%
    5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite
  • HY-108060A
    Valopicitabine dihydrochloride
    		99.79%
    Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
    Valopicitabine dihydrochloride
  • HY-105006
    Spongosine
    Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Spongosine
  • HY-155600
    5′-Guanylyl methylenediphosphonate sodium
    		99.00%
    5′-Guanylyl methylenediphosphonate (sodium) is a GTP analogue and a specific, competitive inhibitor of the GTP reaction in protein synthesis.
    5′-Guanylyl methylenediphosphonate sodium
  • HY-13040
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine
    		99.85%
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N-Benzoyl-5'-O-dmtr-2'-O-(2-methoxyethyl)-adenosine
  • HY-154524
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine
    		99.68%
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    1-(2-Deoxy-β-D-threo-pentofuranosyl)thymine
  • HY-I0100
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
  • HY-W006395
    1-Methylcytosine
    		Chemical ≥98.0%
    1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine.
    1-Methylcytosine
  • HY-50071
    6-Amino-5-nitropyridin-2-one
    		Chemical
    6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine.
    6-Amino-5-nitropyridin-2-one
  • HY-152378
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
  • HY-111531
    DMTr-LNA-5MeU-3-CED-phosphoramidite
    		98.75%
    DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative.
    DMTr-LNA-5MeU-3-CED-phosphoramidite
  • HY-138601
    5'-O-DMT-N4-Bz-5-Me-dC
    		98.72%
    5'-O-DMT-N4-Bz-5-Me-dC is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.
    5'-O-DMT-N4-Bz-5-Me-dC
  • HY-152732
    6-Methyluridine
    		99.02%
    6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    6-Methyluridine